Effects of lipid-lowering agents on inflammation, haemostasis and blood pressure.
Title | Effects of lipid-lowering agents on inflammation, haemostasis and blood pressure. |
Publication Type | Journal Article |
Year of Publication | 2014 |
Authors | Tziomalos, K., Karagiannis A., & Athyros V. G. |
Journal | Curr Pharm Des |
Volume | 20 |
Issue | 40 |
Pagination | 6306-13 |
Date Published | 2014 |
ISSN | 1873-4286 |
Keywords | Blood Pressure, Cholesterol, LDL, Hemostasis, Humans, Hypolipidemic Agents, Inflammation |
Abstract | In addition to the modification of the lipid profile, most lipid-lowering agents appear to modulate other atherogenic pathways. We summarize the effects of lipid-lowering agents on inflammation, hemostasis and blood pressure. We also discuss the potential contribution of these actions on cardiovascular disease prevention. Most lipid-lowering agents appear to exert anti-inflammatory, antithrombotic and antihypertensive effects. These pleiotropic actions appear to contribute to the reduction in cardiovascular events and deep venous thrombosis during statin treatment. Regarding other lipid-lowering agents, it is unclear whether their effects on inflammation, thrombosis or blood pressure play a role in their antiatherogenic potential. |
Alternate Journal | Curr. Pharm. Des. |
PubMed ID | 24953388 |