Non-HLA genes in ankylosing spondylitis: what meta-analyses have shown?
| Title | Non-HLA genes in ankylosing spondylitis: what meta-analyses have shown? |
| Publication Type | Journal Article |
| Year of Publication | 2014 |
| Authors | Chatzikyriakidou, A., Voulgari P. V., & Drosos A. A. |
| Journal | Clin Exp Rheumatol |
| Volume | 32 |
| Issue | 5 |
| Pagination | 735-9 |
| Date Published | 2014 Sep-Oct |
| ISSN | 0392-856X |
| Keywords | Genetic Predisposition to Disease, Humans, Meta-Analysis as Topic, Phenotype, Polymorphism, Genetic, Risk Assessment, Risk Factors, Spondylitis, Ankylosing |
| Abstract | HLA-B27 association with ankylosing spondylitis (AS) is one of the strongest ever reported in the literature. However, only a small proportion of 5-8% of HLA-B27 positive individuals of the general population develops the disease. In recent years, polymorphisms of many non-HLA genes were reported to be associated with AS. In this review, we summarise the current knowledge of non-HLA genetic factors contributing to AS susceptibility based on meta-analyses in order to overcome the limitations of individual genetic studies e.g. the small samples' sizes, the small samples' origin diversities, and the low statistical power of statistical analyses. |
| Alternate Journal | Clin. Exp. Rheumatol. |
| PubMed ID | 25068597 |
