In vitro combination of isavuconazole with micafungin or amphotericin B deoxycholate against medically important molds.
| Title | In vitro combination of isavuconazole with micafungin or amphotericin B deoxycholate against medically important molds. |
| Publication Type | Journal Article |
| Year of Publication | 2014 |
| Authors | Katragkou, A., McCarthy M., Meletiadis J., Petraitis V., Moradi P. W., Strauss G. E., Fouant M. M., Kovanda L. L., Petraitiene R., Roilides E., & Walsh T. J. |
| Journal | Antimicrob Agents Chemother |
| Volume | 58 |
| Issue | 11 |
| Pagination | 6934-7 |
| Date Published | 2014 Nov |
| ISSN | 1098-6596 |
| Keywords | Amphotericin B, Antifungal Agents, Aspergillosis, Aspergillus, Cunninghamella, Deoxycholic Acid, Drug Combinations, Drug Interactions, Echinocandins, Lipopeptides, Microbial Sensitivity Tests, Mucormycosis, Nitriles, Pyridines, Triazoles |
| Abstract | Whether isavuconazole, an extended-spectrum triazole, possesses synergistic activity in combination therapy with echinocandins or amphotericin B for the treatment of invasive molds infections has not been studied. Our in vitro combination studies showed that isavuconazole and micafungin are synergistically active against Aspergillus fumigatus, Aspergillus flavus, Aspergillus terreus, and Cunninghamella bertholletiae. These results suggest that isavuconazole, in combination with micafungin, may have a role in the treatment of invasive aspergillosis and warrants further investigation. |
| DOI | 10.1128/AAC.03261-14 |
| Alternate Journal | Antimicrob. Agents Chemother. |
| PubMed ID | 25136021 |
| PubMed Central ID | PMC4249375 |
| Grant List | T32 AI007613 / AI / NIAID NIH HHS / United States |
