A systems approach identifies co-signaling molecules of early growth response 1 transcription factor in immobilization stress.
Title | A systems approach identifies co-signaling molecules of early growth response 1 transcription factor in immobilization stress. |
Publication Type | Journal Article |
Year of Publication | 2014 |
Authors | Papanikolaou, N. A., Tillinger A., Liu X., Papavassiliou A. G., & Sabban E. L. |
Journal | BMC Syst Biol |
Volume | 8 |
Pagination | 100 |
Date Published | 2014 |
ISSN | 1752-0509 |
Keywords | Animals, Chromogranin B, Early Growth Response Protein 1, Immobilization, Microarray Analysis, Prolactin-Releasing Hormone, Rats, Signal Transduction, STAT3 Transcription Factor, Stress, Physiological, Systems Biology |
Abstract | BACKGROUND: Adaptation to stress is critical for survival. The adrenal medulla, the major source of epinephrine, plays an important role in the development of the hyperadenergic state and increased risk for stress associated disorders, such as hypertension and myocardial infarction. The transcription factor Egr1 plays a central role in acute and repeated stress, however the complexity of the response suggests that other transcription factor pathways might be playing equally important roles during acute and repeated stress. Therefore, we sought to discover such factors by applying a systems approach.RESULTS: Using microarrays and network analysis we show here for the first time that the transcription factor signal transducer and activator of transcription 3 (Stat3) gene is activated in acute stress whereas the prolactin releasing hormone (Prlh11) and chromogranin B (Chgb) genes are induced in repeated immobilization stress and that along with Egr1 may be critical mediators of the stress response.CONCLUSIONS: Our results suggest possible involvement of Stat3 and Prlh1/Chgb up-regulation in the transition from short to repeated stress activation. |
DOI | 10.1186/s12918-014-0100-8 |
Alternate Journal | BMC Syst Biol |
PubMed ID | 25217033 |
PubMed Central ID | PMC4363937 |
Grant List | NS28869 / NS / NINDS NIH HHS / United States |