The WELCOME system is an innovative telemonitoring system designed to provide constant monitoring of COPD patients also suffering from other major comorbidities. It consists of a sensors vest capable of recording various vital parameters in real time and transmitting them to the cloud via a tablet PC and wireless connection. In addition, peripheral devices record extra physiological data which is coupled with responses to validated health questionnaires that the patient responds to via the tablet. A dedicated medical decision support system (DSS) and a medical professional user interface support the system in providing automated detection of abnormal conditions. The obtained signals included Heart and Respiratory Rate, Body Posture, SpO2, multi-lead ECG, Auscultation and Electric Impedance Tomography. The system is tested with pilot studies in two European countries, Greece and UK. The preliminary results from the Greek pilot study are presented in this paper, highlighting the main findings from the first operational use of the WELCOME infrastructure.