Individualized significance of the -251 A/T single nucleotide polymorphism of interleukin-8 in severe infections.
Title | Individualized significance of the -251 A/T single nucleotide polymorphism of interleukin-8 in severe infections. |
Publication Type | Journal Article |
Year of Publication | 2016 |
Authors | Georgitsi, M. D., Vitoros V., Panou C., Tsangaris I., Aimoniotou E., Gatselis N. K., Chasou E., Kouliatsis G., Leventogiannis K., Velissaris D., Belesiotou E., Dioritou-Aggaliadou O., Giannitsioti E., Netea M. G., Giamarellos-Bourboulis E. J., Giannikopoulos G., Alexiou Z., Voloudakis N., & Koutsoukou A. |
Corporate Authors | Hellenic Sepsis Study Group |
Journal | Eur J Clin Microbiol Infect Dis |
Volume | 35 |
Issue | 4 |
Pagination | 563-70 |
Date Published | 2016 Apr |
ISSN | 1435-4373 |
Keywords | Adolescent, Adult, Aged, Aged, 80 and over, Bacterial Infections, Female, Genetic Predisposition to Disease, Genotype, Humans, Interleukin-8, Male, Middle Aged, Polymorphism, Single Nucleotide, Young Adult |
Abstract | Based on the concept of the individualized nature of sepsis, we investigated the significance of the -251 A/T (rs4073) single nucleotide polymorphism (SNP) of interleukin (IL)-8 in relation to the underlying infection. Genotyping was performed in 479 patients with severe acute pyelonephritis (UTI, n = 146), community-acquired pneumonia (CAP, n = 109), intra-abdominal infections (IAI, n = 119), and primary bacteremia (BSI, n = 105) by restriction fragment length polymorphism of the polymerase chain reaction (PCR) product and compared with 104 healthy volunteers. Circulating IL-8 was measured within the first 24 h of diagnosis by an immunosorbent assay. Carriage of the AA genotype was protective from the development of UTI (odds ratio 0.38, p: 0.007) and CAP (odds ratio 0.30, p: 0.004), but not from IAI and BSI. Protection from the development of severe sepsis/septic shock was provided for carriers of the AA genotype among patients with UTI (odds ratio 0.15, p: 0.015). This was accompanied by greater concentrations of circulating IL-8 among patients with the AA genotype. It is concluded that carriage of rs4073 modifies susceptibility for severe infection in an individualized way. This is associated with a modulation of circulating IL-8. |
DOI | 10.1007/s10096-015-2571-y |
Alternate Journal | Eur. J. Clin. Microbiol. Infect. Dis. |
PubMed ID | 26768584 |